Both patients continue to report reduced overall seizure counts of >90% at one year- and seven-months post NRTX-1001 administration, respectively. San Francisco, CA, June 15, 2023 - Neurona Therapeutics NRTX-1001 in people with drug-resistant mesial temporal lobe epilepsy (MTLE).NRTX-1001 NRTX-1001,David Blum, M.D., Cory R. Nicholas, Ph.D. NCT05135091 Dcouvrez comment nous utilisons vos donnes personnelles dans notre Politique de confidentialit et notre Politique relative aux cookies. Relatedly, the NRTX-1001 trial has received clearance from the FDA to expand enrollment to include adults who have MTLE in the verbal memory-dominant lobe and are at greater risk of cognitive decline from a tissue-destructive lobectomy or ablation surgery. We continue to enroll patients in the first cohort of the study and look forward to providing additional updates later this year., Both patients entered the clinical trial with significant seizure activity, impaired cognition, and suboptimal quality of life, said Cory R. Nicholas, Ph.D., Neuronas chief executive officer who gave one of the presentations at the meeting. Lees ons privacybeleid en cookiebeleid voor meer informatie over hoe we je persoonlijke gegevens gebruiken. Working at Neurona Therapeutics | Glassdoor Patient recruitment is underway at epilepsy centers across the United States. Neurona Therapeutics to Present at the Piper Sandler 33rd Annual SAN FRANCISCO, June 22, 2021 (GLOBE NEWSWIRE) -- Neurona Therapeutics Inc., a biotherapeutics company developing neural cell therapies for the treatment of chronic neurological disorders, today . Neurona Therapeutics Presents Preclinical Data from Lead - GlobeNewswire Experienced leader with a broad background in the fields of neuroscience, stem cell biology and preclinical development of cell-based therapeutics. NRTX-1001 has the potential to durably restore neural inhibition to seizure-onset foci following a single administration of cells.. Lorsque vous utilisez nos sites et applications, nous utilisons des, authentifier les utilisateurs, appliquer des mesures de scurit, empcher les spams et les abus; et. SAN FRANCISCO, June 17, 2022 (GLOBE NEWSWIRE) -- Neurona Therapeutics, a clinical-stage biotherapeutics company advancing regenerative cell therapies for the treatment of neurological. Data presented by Marina Bershteyn, Ph.D., who co-directs Neuronas discovery research department, describe the characterization of NRTX-1001, a cell therapeutic produced from human pluripotent stem cells using Neuronas proprietary process in the companys in-house manufacturing facility. After 25 Years of Hype, Embryonic Stem Cells are Still Waiting for Their Moment, July 26, 2023 Neurona Therapeutics Dosed Initial Subject in First Clinical Trial of This funding will support the advancement of our lead candidate, NRTX-1001, into a first-in-human clinical trial we hope to initiate this year for chronic focal-onset epilepsy, an important step toward our ultimate goal of providing safe and effective cell therapies for the treatment of devastating, drug-resistant neurological disorders., Dr. Whittaker added, We see cell therapy as a promising approach for chronic disorders of the nervous system for which current treatment options are not optimal. Nous, Yahoo, faisons partie de la famille de marques Yahoo. Neurona is developing allogeneic, off-the-shelf neural cell therapies for multiple chronic neurological disorders. lwolffe@wheelhouselsa.com, Phase I/II NRTX-1001 for epilepsy on clinicaltrials.gov, Visiting Scientists & Internship programs. SAN FRANCISCO, Feb. 14, 2023 (GLOBE NEWSWIRE) -- Neurona Therapeutics, a clinical-stage biotherapeutics company advancing regenerative cell therapies for the treatment of neurological. Patients treated with a single infusion of NRTX-1001 cells will be monitored for safety, tolerability, neural cell viability, and effects on their epilepsy disease symptoms. It is with great pleasure that we welcome Dr. Whittaker to our Board of Directors. NRTX-1001 is manufactured in Neuronas in-house GMP facility, using proprietary methods to guide the cells into a specific, pallial-type, lineage of interneurons that secrete the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Je kunt je keuzes te allen tijde wijzigen door te klikken op de links 'Privacy- en cookie-instellingen' of 'Privacydashboard' op onze sites en in onze apps. In addition, this patient has shown improved memory performance on cognitive tests. The objective of NRTX-1001 is to add cells that have the potential to repair the circuits that are damaged in epilepsy and thus reduce seizure activity. said Robert Beach, M.D., Ph.D. professor of neurology at SUNY Upstate Medical University. Vous pouvez modifier vos choix tout moment en cliquant sur les liens Paramtres de confidentialit et des cookies ou Tableau de bord sur la confidentialit prsents sur nos sites et dans nos applications. For more information about Neurona, visitwww.neuronatherapeutics.com, Sylvia Wheeler About Mesial Temporal Lobe Epilepsy (MTLE)MTLE primarily affects the internal structures of the temporal lobe, where seizures often begin in a structure called the hippocampus. Visit www.UCBVentures.com, Sylvia Wheeler Individuals with dominant lobe disease have an even greater need for less invasive options that have the potential to be disease-modifying, like NRTX-1001, and we are encouraged that our clinical trial is now open to these individuals., We are delighted with the FDAs decision, which enables enrollment of patients with focal epilepsy that originates in either the dominant or the non-dominant hemisphere and will effectively double the eligible patient population. Neurona is developing off-the-shelf, allogeneic neural cell therapy candidates that are designed to provide long-term repair of dysfunctional neural networks for multiple neurological disorders. The second stage will consist of a randomized, blinded investigation of NRTX-1001 compared to a control group to determine safety and efficacy in up to 30 people with MTLE. Latest Press Releases. SAN FRANCISCO, June 15, 2023 (GLOBE NEWSWIRE) -- Neurona Therapeutics, a clinical-stage biotherapeutics company advancing regenerative cell therapies for the treatment of neurological. About NeuronaNeuronas cell therapies have single-dose curative potential. Patients treated with a single infusion of NRTX-1001 cells will be monitored for safety, tolerability, and effects on their epilepsy disease symptoms. Neurona Therapeutics | LinkedIn In addition, neuropsychological testing suggests an improvement in memory after NRTX-1001 administration. She has a Ph.D. in molecular biology and an MBA. swheeler@wheelhouselsa.com, Elizabeth Wolffe, Ph.D. Cell Care Therapeutics is developing a new class of biologics that are derived from the secreted proteins and exosomes of mesenchymal stromal cells (MSCs). SAN FRANCISCO, June 15, 2023 (GLOBE NEWSWIRE) -- Neurona Therapeutics, a clinical-stage biotherapeutics company advancing regenerative cell therapies for the treatment of neurological. afficher des publicits et des contenus personnaliss en fonction de vos profils de centres dintrt; mesurer lefficacit des publicits et contenus personnaliss; et. No adverse anatomical or behavioral effects were detected in extensive preclinical studies. Neurona Therapeutics Presents Updated Data from the NRTX - BioSpace July 31, 2023 Neurona Therapeutics to Present Preclinical Data Supporting - GlobeNewswire Neuronas multi-center, Phase 1/2 clinical trial is designed to evaluate the safety, tolerability, and efficacy of a single administration of NRTX-1001. For more information, please visit www.clinicaltrials.gov (NCT05135091). Patient recruitment is underway at epilepsy centers across the United States. Epilepsy is one of the most common neurological disorders, affecting over three million people in the U.S. of whom approximately one-third have drug-resistant disease. Wheelhouse LSA Neurona is focused on developing regenerative cell therapy candidates that have single-dose curative potential. Patient recruitment is underway at epilepsy centers across the United States. However, the current surgical options are not available or effective for all, are tissue-destructive, and can have significant adverse effects. I would like to thank the excellent team at SUNY Upstate Medical University who treated the first patient, as well as our other clinical sites across the country who are part of this multicenter study., Neuronas regenerative cell therapy approach has the potential to provide a single-administration, non-destructive alternative for the treatment of drug-resistant focal epilepsy, Currently, people with mesial temporal lobe epilepsy who are not responsive to anti-seizure medications have few options, such as an invasive surgery that removes or destroys the affected brain tissue. said Harish Babu, M.D., Ph.D., assistant professor of neurosurgery at SUNY Upstate Medical University and the surgeon who administered the first dose of NRTX-1001. Neurona Therapeutics, South San Francisco, California, UNITED STATES, NRTX-1001 administration is well-tolerated and shows seizure reduction of >90% in the first two patients at six- and three-months post-treatment, respectively, Data & Safety Monitoring Board (DSMB) has cleared the study to complete enrollment of the first patient cohort. The first stage of the clinical trial is supported by a recently announced $8.0 million grant from the California Institute for Regenerative Medicine (CIRM) (CLIN2-13355). Company profile page for Neurona Therapeutics Inc including stock price, company news, press releases, executives, board members, and contact information We are grateful to the patients, caregivers, and our clinical collaborators for their participation in this first in human clinical study.. NRTX-1001 interneurons are cryopreserved and shipped to clinical sites to be used as an allogeneic, off-the-shelf investigative therapy. About MTLE MTLE primarily affects the internal structures of the temporal lobe, where seizures often begin in a structure called the hippocampus. Neurona TherapeuticsInvestor and Media Contacts: Sylvia WheelerWheelhouse LSAswheeler@wheelhouselsa.com, Elizabeth Wolffe, Ph.D.Wheelhouse LSAlwolffe@wheelhouselsa.com, Inside KCON LA 2023, an extravagant microcosm of K-pop's macro influence, Oil Holds Loss on Signs of Supply Rebound as Demand Woes Linger, BRICS leaders meet in South Africa as bloc weighs expansion, Dubai International Airport sees 41.6 million passengers in first half of year, more than in 2019, Indonesia, Boeing sign deal for sale of F-15 fighter jets. Following a single treatment with NRTX-1001, which has been well tolerated with no serious or severe adverse events, both patients have thus far experienced impressive, early reduction in seizure activity. The preliminary data demonstrate promising reduction (>90%) in seizure frequency in the first and second patients at one year and seven-months post-treatment, respectively. The pipeline includes neuronal, glial, and gene-edited cell therapy candidates led by NRTX-1001, a first-in-class inhibitory neuron therapy for epilepsy. The fully-differentiated neural cells, called interneurons, secrete the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). For people with seizures resistant to anti-seizure drugs, epilepsy surgery - where the damaged temporal lobe is surgically removed or ablated by laser - can be an option. Wheelhouse LSA Neurona is a clinical-stage biotherapeutics company developing regenerative cell therapies that permanently integrate into neural circuits, replace affected cells, and rebalance dysregulated electrical activity to repair the nervous system. Vous pouvez modifier vos choix tout moment en cliquant sur les liens Paramtres de confidentialit et des cookies ou Tableau de bord sur la confidentialit prsents sur nos sites et dans nos applications. Neither subject has experienced a serious adverse event, and the data safety monitoring board has reviewed their progress and allowed the study to continue enrollment. Nous, Yahoo, faisons partie de la famille de marques Yahoo. About us | Rubicon Biotechnology The clinical study is designed to evaluate the safety and efficacy of a single administration of NRTX-1001 for drug-resistant MTLE. For people resistant to anti-seizure drugs, epilepsy surgery, where the damaged temporal lobe is surgically removed or ablated by laser, can be an option. Prior to joining UCB, Erica spent 10 years as a top-ranked biotechnology equity analyst for Merrill Lynch in London. Neurona Therapeutics Appoints James Stutz as Chief Financial - BioSpace SAN FRANCISCO, July 31, 2023 (GLOBE NEWSWIRE) -- Neurona Therapeutics, a clinical-stage biotherapeutics company advancing regenerative cell therapy candidates for the treatment of neurological disorders, today announced the appointment of James Stutz, a business and finance executive with over 20 years of experience in the biopharma industry, as chief financial officer (CFO) and chief business . Neurona Therapeutics Raises $41.5M to Advance Neural Network - BioSpace In October 2020, the patienta seven-year-old sea lion named Cronuttunderwent an experimental brain surgery that involved transplanting healthy pig neurons into his damaged hippocampus. dvelopper et amliorer nos produits et services. The nerve cells, called interneurons, secrete the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). San Francisco, CA, June 22, 2021 - Neurona Therapeutics Inc., a biotherapeutics company developing neural cell therapies for the treatment of chronic neurological disorders, today announced the successful completion of a $41.5 million financing. NRTX-1001 interneurons are cryopreserved and shipped to clinical sites to be used as an allogeneic, off-the-shelf investigative therapy.
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