The concentrations of thyroid hormones T4 and T3 were significantly lower in the exposed workers than in the controls (T4: 78.0 5.2 versus 109.4 2.0nmol/litre, P < 0.05; T3: 1.2 0.1 versus 3.8 0.1nmol/litre, P < 0.001). Rats received, over a 2-week period, 0.05% thiourea (25 mg/kg body weight per day) up to 2% thiourea (1000 mg/kg body weight per day) in food. In the middle of the production hall, the air concentration was 3.9 Palpation of the testes of treated lambs revealed hydrocoele with small testes. WebSeveral synthetic strategies using copper(I) starting materials or copper(II) compounds and an in situ sulfite reductant have been used to systematically explore the chemistry of copper(I) complexes with thiourea and substituted thiourea ligands. Kanerva L, Estlander T, Jolanki R (2000) Occupational allergic contact dermatitis from trichlorozincates of 4-(dimethylamino)benzendiazonium (Diazo A) and 3-methyl-4-(pyrrolidin-1-yl)benzenediazonium (Diazo Y) and thiourea in diazo copy paper. From the available degradation tests and taking into account the expected environmental distribution of thiourea, leaching of this compound from soil to ground-water seems possible, particularly under conditions unfavourable for biotic degradation. An investigation at a textile factory on the prevalence of hypothyroidism gave typical concentrations of 5 g thiourea/m3 at an inlet of the local exhaust ventilation of the finishing machines. The inhibitory effect of thiourea on the induction of DNA strand breakage due to various intercalating substances in mouse leukaemia cells might be the result of a change in chromatin structure. Tokyo, Department of Environmental Health, Office of Health Studies, pp. Es soluble en agua (137g/l a 20C) y en disolventes orgnicos polares prticos y aprticos e insoluble en disolventes no polares. Blume H, Ahlsdorf B (1993) Prediction of pesticide behavior in soil by means of simple field tests. Thiourea at concentrations of 1040 mmol/litre induced a 5-fold increase in the frequency of azaguanine-resistant V79 Chinese hamster cells (while the cytotoxicity was less than 15%) in the absence of a metabolic activation system (Ziegler-Skylakakis et al., 1985). thiourea At 182 C (360 F), thiourea crystallises as colourless crystals. In two studies on ready biodegradability, no mineralization of thiourea was observed (TNO, 1990; MITI, 1992). Toxicology and Applied Pharmacology, 11:88103. Water Eight male lambs aged 33.5 months were orally administered 50 mg thiourea/kg body weight daily for 3.5 months (Sokkar et al., 2000). Geneva, World Health Organization, International Programme on Chemical Safety (ICSC 0680). The possible molecular Water soluble: soluble thiourea is more soluble in methanol than in water, and at temperat,ures above that point is more soluble in water than in methanol, when expressed on the mol fraction basis. For immobilization of D. magna, a 96-h EC50 value of 1.8 mg/litre was determined. The extinction coefficients epsilonmax at lambdamax (235 and 238 nm) are in the range of 1100012590/mol per second (Weast & Astle, 1979; Fesch et al., 1998). Thiourea has been identified as one of the metabolites in workers exposed to carbon disulfide (Pergal et al., 1972). For the terrestrial compartment, toxicity tests on microorganisms, higher plants, earthworms, nematodes, and insects are available. Une tude du mme genre effectue sur des agneaux mles a montr que la thioure avait un effet nocif sur le dveloppement de lappareil reproducteur. In 5 of 20 rats treated with DHPN and thiourea, thyroid follicular cell adenomas occurred. There is the possibility of contact with blueprint paper at the workplace (architects, engineers, engineering draughtsmen). In two long-term tests with D. magna, 21-day NOEC values of <0.25 mg/litre and 0.25 mg/litre were established for reproduction. Qualitative analysis of organic mixture (Binary Terrestrial plants proved to be generally more sensitive. Thiourea Is thiourea flammable? Contact dermatitis and photocontact dermatitis upon dermal exposure have been described during thiourea production and also after handling products containing thiourea, such as diazo copy paper and silver polish. A quantification of the thiourea releases from all the different industrial sources is not possible with the available data. Klinicheskaya Meditsina (Moscow), 42:129132 (in Russian) [cited in MAK, 1988]. Improvement of the solubilization of proteins in two-dimensional Archives of Environmental Health, 25:4244. XX. WebThiourea dioxide (TUD), also known as formamidine-sulfinic acid (FASA) or aminoiminomethanesulfinic acid (AIMS), is an organosulfur compound with white or pale yellow color; it is an odorless crystalline powder which is stable both in solid form and in cold aqueous solution. WebMaleic acid is more soluble in water than fumaric acid. Purves HD, Griesbach WE (1947) Studies on experimental goitre. Consumer exposure to thiourea can occur from the metabolism of thiourea-based pharmaceuticals. Thiourea water). The latter has been shown to be genotoxic in cultured mammalian cells (Ziegler-Skylakakis, 1998). Daprs les donnes exprimentales fiables dont on dispose au sujet de la toxicit de ce compos pour les espces terrestres et aquatiques, compte tenu en outre de son faible potentiel de bioaccumulation et de son devenir environnemental probable aprs rejet dans leau ou le sol, il ne semble pas que la thioure prsente un risque important pour les organismes terrestres ou aquatiques, sauf en cas de dversement accidentel. Stelzner TJ, Welsh CH, Berger E, McCullough RG, Morris K, Repine JE, Wel JV (1987) Antiarrhythmic agents diminish thiourea-induced pulmonary vascular protein leak in rats. Harrison, NY, National Association of Photographic Manufacturers, Inc. NAPM (1974b) Environmental effect of photoprocessing chemicals. Efficient and easy accessibility of thiourea derivatives is an open challenge . Science and Culture, 42:476477. This critical evaluation and the classification of substances are the result of an extensive discussion process by the members of the Commission, proceeding from a draft documentation prepared by members of the Commission, by ad hoc experts, or by the Scientific Secretariat of the Commission. Animals were observed for mortality and moribundity and for overt signs of toxicity. Sarkar SR, Singh L, Uniyal BP (1988) Changes in plasma calcium, magnesium, iron and copper in experimental pulmonary edema in rats. Bhide (1991) investigated the effect of different thiourea concentrations on eggs and nymphs of the red cotton bug (Dysdercus similis), a cotton plant pest. In: Kaiser KE, ed. Thiourea is also used in diazo photosensitive paper, synthetic resin coating, anion exchange resin, germination promoter, fungicide and many other aspects. Kubota M, Asami T (1985) Source of nitrous acid volatilized from upland soils. Thiourea appears as white or off-white crystals or powder. Wagner R, Kayser G (1990) Laboruntersuchungen zur Hemmung der Nitrifikation durch spezielle Inhaltsstoffe industrieller und gewerblicher Abwsser. Dalton AJ, Morris HP, Dubnik CS (1948) Morphologic changes in the organs of female C3H mice after long-term ingestion of thiourea and thiouracil. Thiourea Acute intoxication with thiourea has been linked with an increase in the level of histamine in the lungs and plasma (4.38 g histamine/100 ml plasma was determined for rats administered thiourea intraperitoneally at 10 mg/kg body weight compared with 2.08g/100 ml in the controls) and with an increase in lung vessel permeability (Giri et al., 1991a). Shepard TH (1963) Metabolism of thiourea 35S by the fetal thyroid of the rat. 2. Aprs administration par voie orale des sujets humains ou des animaux, elle est presque totalement absorbe puis excrte en grande partie telle quelle par la voie rnale. WebIn most cases, a water-miscible organic cosolvent was used due to the poor aqueous solubility of biscarbodiimide agents (4). Deichmann WB, Keplinger M, Sala F, Glass E (1967) Synergism among oral carcinogens. McCleskey PE, Swerlick RA (2001) Clinical review: thioureas and allergic contact dermatitis. The estimation of workplace exposure is based on very limited data. Astwood EB, Bissell A, Hughes AM (1945) Further studies on the chemical nature of compounds which inhibit the function of the thyroid gland. IPCS (2000) International Chemical Safety Card Thiourea. BUA (1995) Thiourea. Rheinheimer et al. In addition, proliferative lesions in the thyroid consisting of adenomatous nodules and neoplasias and proliferative lesions in the lung were seen in the rats that received thiourea (Shimo et al., 1994b). Giri SN, Hollinger MA, Rice SA (1991b) Effects of thiourea tolerance on plasma histamine, and lung vascular permeability. Journal of General Microbiology, 64:139150. Thiourea induced chromosomal recombination in yeast and insects. Very similar results had already been reported previously (Lonati-Galligani et al., 1983), although they were (presumably erroneously: see Rossberger & Andrae, 1987) interpreted as constituting a negative response. The process of WTF resin for S/S process of heavy metal contaminated soils was studied. B . This study explored the repair effect of a new resin repair agent water-soluble thiourea-formaldehyde (WTF), and its stability under indigenous biodegradation and compared the repair effect with sodium sulfide (Na 2 S) and hydroxyapatite (HAP). Journal of Veterinary Medicine, Series B, 47(9):641652. 284288. Environment Agency Japan (1985) Report on environmental survey and wildlife monitoring in F.Y. 803815. R 6012). De acuerdo con los datos experimentales fidedignos disponibles sobre la toxicidad para las especies acuticas y terrestres, el bajo potencial de bioacumulacin y el destino previsto en el medio ambiente cuando se libera en el agua o el suelo hacen suponer que la tiourea no representa un riesgo significativo para los organismos de ambos compartimentos del medio ambiente (excepto en el caso de derrame accidental). Thiourea - Sciencemadness Wiki Abschluseminar am 17./18.01.1985: Auswertung und bersicht ueber die durchgefhrten Prfungen: Akkumulation; Bioabbau (SCAS-Test). Central Institute for Nutrition and Food Research, Netherlands, for SKW Trostberg AG, Trostberg (Report No. Solutions were applied topically to larval stages 15 and, for imagos, additionally in the diet. Test (PDF) Synthesis and characterization of thiourea - ResearchGate Toxic doses of thiourea also resulted in hyperglycaemia, glucosuria, polyuria, and a reduction in the liver glycogen level in rats (MAK, 1988). This is a well recognized mechanism of action for non-genotoxic thyroid carcinogens (Capen et al., 1999). Overall, the effect of the chemical was described as being negative in one case (institute A) and positive in the other (institute B). Maternally toxic oral doses of 1000 mg thiourea/kg body weight administered to mice on the 10th day and to rats on the 12th or 14th days of gestation were likewise found to be embryotoxic. Thiourea was used in former times as a thyroid depressant in patients with hyperthyroidism. With respect to freshwater fish, all tests available for short-term exposure revealed LC50 values (48- and 96-h) at or above 100 mg/litre. No thiourea was found in the atmosphere of the process area (Roberts et al., 1990). La produccin anual mundial de tiourea en 1993 fue de unas 10000 toneladas. Due to the lack of measured thiourea concentrations in surface waters and soil, a quantitative risk assessment for these environmental compartments could not be performed. Forschungsbericht 106 02 051. Histopathology of the thyroid gland revealed hyperplasia of the follicle-lining epithelial cells that project into the lumen. Its surface tension is 1.04 10-2 N/m. Although these tumours are likely to be induced by the hypothyroidism, thiourea has also, in some studies, shown weak genotoxic potential, and the mechanism of carcinogenesis is not fully settled. Elle est soluble dans leau (137 g/litre 20C) ainsi que dans les solvants organiques polaires protiques et aprotiques, mais insoluble dans les solvants non polaires. Ziegler-Skylakakis K, Rossberger S, Andrae U (1985) Thiourea induces DNA repair synthesis in primary rat hepatocyte cultures and gene mutations in V79 Chinese hamster cells. EC (1996) Technical guidance document in support of the Commission Directive 93/EEC on risk assessment for new notified substances and the Commission Regulation (EC)1488/94 on risk assessment for existing substances. The lumina were devoid of colloid. Mutation Research, 272:145160. In the eye mosaic assay with D. melanogaster, the application of 0.5 mmol thiourea/litre yielded positive results with respect to end-point interchromosomal mitotic recombination, whereas the concentration of 1.0 mmol/litre proved to be lethal (Vogel & Nivard, 1993). Fischer H (1985) berprfung der Durchfhrbarkeit von Prfungsvorschriften und der Aussagekraft der Stufen 1 und 2 des Chemikaliengesetzes 25-Stoffe-Programm FE-Vorhaben 10604 011. When rabbit skin was exposed to 0.5 g of thiourea for a period of 4 h, the substance was tolerated without reaction (Korte & Greim, 1981). FV (1991) Forschungsvorhaben "Bewertung wassergefhrdender Stoffe - Teil III" Nitrifikationshemmtest - Leuchtbakterienhemmtest. By virtue of its tendency to form porous frameworks, urea has the ability to In studies with pregnant ewes administered 50 mg thiourea/kg body weight daily for 2, 4, or 6 months, abortion, stillbirth, birth of weak/low-weight lambs, dystokia, and retention of placenta were common features. Les donnes exprimentales que lon possde au sujet de la bioaccumulation de ce compos indiquent quil nexiste pas de possibilit de bioaccumulation de la thioure dans les organismes aquatiques. Environmental and Molecular Mutagenesis, 14(Suppl. Thiourea in concentrations of 0.5 and 1.0 mmol/litre nutrient solution had a positive effect in the zeste-white test system of Drosophila melanogaster, whereas equivocal results were obtained with the same concentrations in the white-ivory test system (Batiste-Alentorn et al., 1991, 1994). Toxicology Letters, 57:283290. Elevated temperature was observed almost immediately after commencement of the therapy and regressed upon its termination. They determined a 28-day LC50 of 3550 mg/kg soil dry weight. The prevalence for women was less remarkable when compared with the rate of 19/1000 found for women in the same survey. It is poisonous, albeit the lethal dose has not been determined. Peters JP, Man EB, Kydd DM, Engstrom WW, Waters LL (1949) Toxic effects of antithyroid drugs. Magnusson B, Kligman A (1970) Allergic contact dermatitis in the guinea pig. THIOUREA Journal of Investigative Dermatology, 81:275278. Slanina P, Ullberg S, Hammarstroem L (1973) Distribution and placenta transfer of 14C-thiourea and 14C-thiouracil in mice studied by whole-body autoradiography. Sokkar S, Soror A, Ahmed Y, Ezzo O, Hamouda M (2000) Pathological and biochemical studies on experimental hypothyroidism in growing lambs. Indian Journal of Animal Science, 57:383387. In: Chemicals in the environment. Pemberton, Wilmslow, United Kingdom; European Chemical Industry Council / European Centre for Ecotoxicology and Toxicology of Chemicals (CEFIC/ECETOC), Mr W. Stott, Dow Chemical Company, Midland, MI, USA; European Chemical Industry Council / European Centre for Ecotoxicology and Toxicology of Chemicals (CEFIC/ECETOC), Mr J.M. I. Toxicology, 60:245251. Based on the physicochemical properties of thiourea and its use pattern, the hydrosphere is expected to be the main target compartment for this compound. According to the classification scheme of Blume & Ahlsdorf (1993), the sorption of thiourea onto organic matter of three different soils may be characterized as low (spodosol) to moderate (entisol/alfisol). Krieter PA, Ziegler DM, Hill KE, Burk RF (1984) Increased biliary GSSG efflux from rat livers perfused wth thiocarbamide substrates for the flavin-containing monooxygenase. Journal of Soil Contamination, 1(4):339360. Seiler (1977) found no inhibition of the incorporation of [3H]thymidine into testicular DNA due to thiourea in vivo using the Friedman-Staub test (Friedman & Staub, 1976). Hashimoto A (1979) Salting-out chromatography applied to separation and analysis of mixtures of thioureas and thioacetamide by high performance liquid chromatography. Background Information. (57) A novel water-soluble thiourea dioxide derivative is produced by contacting thiourea dioxide with an aqueous solution comprising an amino acid having the general formula NH2(CH2)nCOOH wherein n is an integer of 1 to 7 and a sodium, potassium or calcium Through leaching experiments, WTF can stabilize 93.0% of Cd 2+ and 99.7% of Cu 2+. Central Institute for Nutrition and Food Research, Netherlands, for SKW Trostberg AG, Trostberg, 8 pp. Hazleton Laboratories America Inc. for SKW Trostberg AG, Trostberg, pp. Il peut galement y avoir exposition lors de lutilisation de produits faire briller les mtaux base de thioure ou lors de la mtabolisation de produits pharmaceutiques contenant cette molcule.
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